Kremer S, Lersy F, Anheim M, et al. - In this retrospective multicenter study incorporating 11 hospitals, researchers characterized neuroimaging findings and recorded the epidemiologic and clinical features of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. The sample consisted of 64 patients (43 men and 21 women), with a median age of 66 (range 20–92) years, with confirmed COVID-19 with neurologic manifestations who had a brain MRI. The most frequent neuroimaging findings were ischemic strokes, leptomeningeal enhancement, and encephalitis. The most common neurologic manifestation was confusion, followed by impaired consciousness, presence of clinical signs of corticospinal tract involvement, agitation, and headache. A wide range of neurologic symptoms can occur in patients with COVID-19, which may be associated with severe and fatal complications like ischemic stroke or encephalitis. In terms of involvement of meningoencephalitis, pathophysiology seems to involve an immune or inflammatory process, even though a direct effect of the virus can not be excluded, given the existence of signs of inflammation in both CSF and neuroimaging but the lack of virus in CSF.