David JM, et al. - In the neoadjuvant treatment of locally advanced rectal cancer (LARC), researchers compared intensity modulated radiotherapy (IMRT) vs advanced pre-treatment imaging and the impact on toxicities and pathologic outcomes vs 3-dimensional conformal radiotherapy (3DCRT). They reviewed LARC patients treated at 4 large academic centers in the US from 2007–2016. Findings demonstrated that reduced acute toxicities and improved PR were achieved with neoadjuvant chemoradiation (NeoCRT) IMRT with pretreatment positron emission tomography (PET) and/or magnetic resonance imaging (MRI) for LARC vs 3DCRT. They recommended IMRT with pretreatment PET and/or MRI be considered standard treatment for LARC.