Clarke N, Kearney PM, Gallagher P, et al. - Among people invited to a population-based screening program, researchers discussed awareness, perceptions about cancer, subjective health literacy, emotional attitudes to screening, and social influences. Regression modelling of a cross-sectional survey of 2,299 people (users and non-users) of a population-based Fecal Immunochemical Test (FIT) screening program in Dublin was performed. Non-participation in FIT (−based screening) is correlated with negative cancer-related and screening-related beliefs and emotions. Lower uptake of screening was predicted by stronger fatalistic beliefs and agreement that the test was disgusting and tempting fate. Lower uptake was also seen among participants aged <65 who disagreed that “cancer can often be cured,” while the influence of a partner on decision to be screened was associated with higher uptake. The correlation between the influence of a partner and screening participation poses a challenge around enhancing uptake among those not in co-habiting relationships.