Valasapalli S, Guddati AK, et al. - According to an analysis of the SEER database from 2000 to 2018 including men and women belonging to four ethnic groups (ie, Black/African Americans, White/Caucasian, American Indian/Alaska natives, and Asian/Pacific Islanders), it is evident that ocular and orbital melanoma are uncommon cancers that primarily affect Caucasians and White people.

• This study found that incidence-based mortality for these patients has been worsening over the last two decades.

• Such entities have a poor prognosis and have received little attention in immunotherapy trials.

• From 2000 to 2018, Caucasian/White patients had the highest incidence-based mortality, followed by African American/Black and Asian/Pacific Islander patients.

• Patients who are American Indian or Alaskan natives appear to have the lowest mortality rate.

• Between 2000 and 2018, there was a statistically significant difference in mortality among Caucasian/White patients, African American/Black patients, and Asian/Pacific Islander patients.

• For African American/Black and American Indian/Alaskan native patients, the sample size was insufficient to detect a meaningful trend in mortality.

• In general, Caucasian males and females appear to have a much higher and worsening incidence-based mortality rate than other races.

• New clinical trials are required to help improve mortality rates.