Guitton C, et al. - In this randomized controlled trial (the PROTRACH study) that involved 192 non-severely hypoxemic patients requiring intubation in the intensive care unit (ICU), researchers assessed preoxygenation with high-flow therapy by nasal cannulae (HFNC) vs standard bag-valve mask oxygenation (SMO) during rapid sequence intubation (RSI). HFNC was sustained throughout the intubation process; SMO, on the other hand, was removed to perform laryngoscopy. The lowest pulse oximetry (SpO₂) throughout the intubation procedure was the primary focus. Also, drop in SpO₂, adverse events related to intubation, and outcome in the ICU were assessed as secondary outcomes. According to findings, no improvement in the lowest SpO₂ during intubation resulted from preoxygenation with HFNC vs SMO in the ICU, but preoxygenation with HFNC led to a reduction in intubation-related adverse events.