Sio TT, Blanchard MJ, Novotny PJ, et al. - Through a prospective pilot double-blind, placebo-controlled randomized clinical trial (Alliance MC13C2) of 32 adult individuals who had undergone chemoradiotherapy, researchers discovered whether N-acetylcysteine rinse was safe and could enhance thickened secretions and dry mouth during and following radiotherapy. Baseline features were balanced for placebo (n = 17) and N-acetylcysteine (n = 15). For improving sticky saliva, N-acetylcysteine was better. Including sticky saliva daytime, daytime and total xerostomia, pain, and trouble with social eating, scores of multiple secondary endpoints supported N-acetylcysteine. The findings were validated by repeated measures models. The taste was a chief dissatisfier for N-acetylcysteine rinse, although, both testing rinses were safe and well-tolerated overall. Therefore, it was demonstrated that for improving thickened saliva and xerostomia, N-acetylcysteine rinse was safe and gave powerful confirmation of potential efficiency by the patient-reported outcome.