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Mutual risks of cutaneous melanoma and specific lymphoid neoplasms: Second cancer occurrence and survival

Journal of the National Cancer Institute Jul 12, 2018

Herr MM, et al. - In a cohort of Caucasian adults (age 20-83 years) initially diagnosed with cutaneous melanoma (CM) or lymphoid neoplasm (LN) from 17 US population-based cancer registries, researchers estimated the risk for developing CM after specific LNs and, on the other hand, for developing specific LNs after CM, and evaluating clinical effect. They estimated second cancer risk by using standardized incidence ratios (SIRs). Cox regression was used to determine the effect of second cancer development on the risk of all-cause mortality. Findings revealed heterogeneous associations between CM and specific LN subtypes. A shared etiology was indicated by the observed mutual association between CM and certain LN. A substantial decrease of overall survival consequent to the development of second primary CM or LN was also observed.

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