Cheung EW, Zachariah P, Gorelik M, et al. - Researchers sought to report on severe coronavirus disease 2019 (COVID-19) in children. They assessed patients who were 21 years or younger; were hospitalized at Columbia University Irving Medical Center/NewYork-Presbyterian Morgan Stanley Children’s Hospital in New York City between April 18 and May 5, 2020; presented with a clinical syndrome characterized by prolonged fever, systemic inflammation, shock, end-organ dysfunction, or symptoms reminiscent of Kawasaki disease (KD) or toxic shock syndrome (TSS); and had evidence of recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Assessment of 17 patients (8 male; median age, 8 years [range, 1.8-16 years]) was done who developed an inflammatory phenotype related to COVID-19; most of these patients were white (n = 12) and were previously healthy (mild asthma in 3). Features overlapped with, but were different from, those of KD and TSS. The noted cytokine expression patterns infer an interferon signaling component, along with IL-6 and IL-10 production, observed in KD and acute pulmonary COVID-19 infection. There were no elevated TNF-α or IL-13 levels that may differ from acute pulmonary COVID infections. Abnormal cardiac findings noted in these cases emphasize the necessity for long-term surveillance.