Cheung EW, Zachariah P, Gorelik M, et al. - Researchers sought to report on severe coronavirus disease 2019 (COVID-19) in children. Per international data, a proinflammatory syndrome with features of Kawasaki disease (KD) or toxic shock syndrome (TSS) develop in children, possibly related to COVID-19. In this study, patients with the following features were assessed: (1) 21 years or younger; (2) hospitalized at Columbia University Irving Medical Center/New York-Presbyterian Morgan Stanley Children’s Hospital in New York City between April 18 and May 5, 2020; (3) presenting with a clinical syndrome characterized by prolonged fever, systemic inflammation, shock, end-organ dysfunction, or symptoms reminiscent of KD or TSS; and (4) evidence of recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. They here described 17 previously healthy children and adolescents (8 male; median age, 8 years [range, 1.8-16 years]) who developed an inflammatory phenotype related to COVID-19. Per observations, features overlapped with, but were different from, those of KD and TSS. In these cases, cytokine expression pattern indicated an interferon signaling component, along with IL-6 and IL-10 production, observed in KD and acute pulmonary COVID-19 infection. The lack of raised TNF-α or IL-13 levels was possibly distinct from acute pulmonary COVID infections. Abnormal cardiac findings observed in these cases suggests the necessity for long-term surveillance.