Dufort EM, Koumans EH, Chow EJ, et al. - In view of the studies reporting the association of corona virus disease 2019 with a multisystem inflammatory syndrome in children (MIS-C), the New York State Department of Health (NYSDOH) established active, statewide surveillance to characterize hospitalized cases with the syndrome. Medical records of cases of Kawasaki’s disease, toxic shock syndrome, myocarditis, and potential MIS-C in hospitalized patients younger than 21 years of age were sent to the NYSDOH by the hospitals in New York State. As of May 10, 2020, the NYSDOH had reports of a total of 191 potential cases. Ninety-five patients had confirmed MIS-C (laboratory-confirmed acute or recent severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infection) and there were 4 patients with suspected MIS-C (met clinical and epidemiologic criteria). Subjective fever or chills were the presenting symptoms in all; 97% had tachycardia, 80% had gastrointestinal symptoms, 60% had rash, 56% had conjunctival injection, and 27% had mucosal changes. Elevated level of C-reactive protein was found in 100%, of d-dimer in 91%, and of troponin in 71% of the patients; 62% were provided vasopressor support, 53% had evidence of myocarditis, 80% were admitted to an intensive care unit, and 2 died. The median length of hospital stay was 6 days. Observations suggest that in New York State, the emergence of multisystem inflammatory syndrome in children coincided with widespread SARS-CoV-2 transmission. Further, cardiac dysfunction was noted in correlation with this hyperinflammatory syndrome with dermatologic, mucocutaneous, and gastrointestinal manifestations.