Majumdar UB, Hunt C, Doupe P, et al. - In this retrospective cross-sectional study of 192,085 adults plan members of capitated Medicaid contracts between the Healthfirst managed care organization and the Mount Sinai Health System in the years 2012 to 2014 in New York City, USA, researchers investigated the burden of multiple chronic conditions (MCC) in an urban health system, and suggested a methodology to recognize subpopulations of interest-based on diagnosis groups and costs. About 61.5% of the study population had two or more chronic conditions. The most prevalent dyad was hypertension and hyperlipidemia and the most common triad was diabetes, hypertension, and hyperlipidemia. The principal cost segment in the study population was women aged 50 to 65 with hypertension and hyperlipidemia. With a number of conditions and ages, costs and predominance of MCC rise. Pulmonary disease and myocardial infarction were the disease dyads related to the largest seen/expected ratios. The inter-borough range MCC predominance was 16%. Thus, MCC is more common vs nationally in this low-income, urban population, encouraging additional research and intervention in this population. By recognizing possible target populations in an interpretable fashion, this segmenting methodology has use for health services analysts.