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Multiparametric early detection and prediction of cardiotoxicity using myocardial strain, T1 and T2 mapping, and biochemical markers: A longitudinal cardiac resonance imaging study during 2 years of follow-up

Circulation: Cardiovascular Imaging Jun 19, 2021

Giusca S, Korosoglou G, Montenbruck M, et al. - The present study was conducted to examine the ability of cardiovascular magnetic resonance for detecting and predicting cardiac dysfunction in patients receiving cancer therapy. Researchers recruited a total of 61 individuals (47 with breast cancer, 11 with non-Hodgkin lymphoma, and 3 with Hodgkin lymphoma) who had undergone cardiovascular magnetic resonance scans at baseline and at regular intervals during 2 years of follow-up. Researchers examined the percentage of all left ventricular myocardial segments with strain ≤−17% (normal myocardium [%]). They characterized clinical cardiotoxicity (CTX) and sub-CTX according to standard measures. This study’s findings demonstrate that normal myocardium (%) derived by fast-strain-encoded cardiovascular magnetic resonance, is an accurate and sensitive tool that can establish cardiac safety in patients with cancer undergoing cardiotoxic chemotherapy not only for the early detection but also for the prediction of those at risk of developing CTX.

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