Ueki K, Sasako T, Okazaki Y, et al. - Researchers examined the effects of an intensified multifactorial intervention (intensive therapy treatment targets; HbA1c under 6.2%, blood pressure under 120/75 mmHg, low-density lipoprotein cholesterol under 80 mg/dL) comparing with the step-wise intensification of medications and lifestyle modifications of guideline-based standard care (conventional therapy treatment targets: HbA1c under 6.9%, blood pressure under 130/80 mmHg, low-density lipoprotein cholesterol under 120 mg/dL) on diabetic kidney disease to investigate the impact of a multifactorial intervention on the onset and progression of diabetic kidney disease in the patients with type 2 diabetes. They randomly assigned a sum of 2,540 eligible patients in the Japan Diabetes Optimal 101 Integrated Treatment for three major risk factors of coronary diseases cohort to intensive therapy and conventional therapy and treated for a median of 8.5 years. In comparison with conventional therapy, intensive therapy was correlated with a significant 32% reduction in kidney events and was associated with a change in HbA1c at one year from study initiation. Therefore, prespecified analysis exhibits that intensified multifactorial intervention significantly decreased the onset and progression of diabetic kidney disease in comparison with currently recommended care.