Multi-fetal pregnancy, preeclampsia, and long-term cardiovascular disease
Hypertension Jun 15, 2020
Bergman L, Nordlöf-Callbo P, Wikström AK, et al. - Researchers investigated the individual as well as the integrated contribution of preeclampsia and multi-fetal pregnancy on a woman’s risk of cardiovascular disease (CVD) later in life, by performing this Swedish register-based cohort study. They found an increased risk of CVD in women with preeclampsia in a singleton pregnancy vs females who had a singleton pregnancy without preeclampsia (the referent group). No increased risk of future CVD was noted in women who had a multi-fetal pregnancy without or with preeclampsia. Experts identified no link between preeclampsia in a first multi-fetal pregnancy and increased risk of future CVD, vs preeclampsia in a first singleton pregnancy. This may lend support to the hypothesis that the larger pregnancy-associated burden on the maternal cardiovascular system as well as excessive placenta-shed inflammatory factors account for a more common occurrence of preeclampsia in multi-fetal pregnancies, instead of the woman’s underlying cardiovascular phenotype.
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