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MS relapses contribute to long term disability

Acta Neurologica Scandinavica Jul 23, 2019

Scott TF, et al. - Using long term data collected in the clinic, researchers determined the contribution of relapse associated disability to overall disability in RMS. A retrospective study was conducted of a cohort of newly diagnosed RMS patients (n=176), measuring all confirmed disability modifications up to 15 years after onset. Worsening was evaluated annually and in five-year epochs and was attributed to either relapse (RW) or slow progression (PW). Over the entire 15 years, the median change in disability due to RW vs PW was similar. During the first 15 years after onset, the aggravation of treated MS was associated with relapses in many RMS patients, suggesting an opportunity for long-term benefit through the reduction of relapse.
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