Suh CH, et al. - Via a systematic review and meta-analysis of 1,182 subjects who underwent at least one MRI sequence, the researchers assessed the diagnostic performance of MRI for differentiating primary central nervous system lymphoma (PCNSL) from glioblastoma. High overall diagnostic performance was exhibited by MRI sequences with pooled sensitivity and specificity of 91% and 89%, respectively. The area under the hierarchical summary receiver operating characteristic curve was observed to be 0.92. Studies using dynamic susceptibility-weighted contrast-enhanced imaging (DSC) or arterial spin labeling (ASL) demonstrated high diagnostic performance. Heterogeneity was only discovered in specificity and magnetic field strength was observed to be an important factor influencing study heterogeneity. Hence, for distinguishing PCNSL from glioblastoma, MRI exhibited overall high diagnostic performance with the help of studies using DSC or ASL demonstrating high diagnostic performance. Furthermore, for distinguishing PCNSL from glioblastoma, MRI sequences including DSC or ASL that was concluded as a potential diagnostic tool.