Motor function and the probability of prodromal Parkinson's disease in older adults
Movement Disorders Jul 22, 2019
Maraki MI, et al. - In a community-dwelling older population, researchers explored the connection between motor function and the likelihood of prodromal PD using data from a population-based cohort of older adults (HELIAD study). They assessed subjective motor function with a 12-item motor symptoms questionnaire and objective motor function indirectly with two gait speed tests and a physical activity questionnaire. Based on the Movement Disorder Society research criteria, the likelihood of prodromal PD was calculated for 1,731 without PD. To examine the relationships between each motor measure and prodromal PD likelihood, regression multiadjusted models were used. A higher likelihood of prodromal PD in older adults is linked to subjective motor symptoms as well as simple objective motor measures of physical activity or gait speed. There was a 27% and 3% higher likelihood for prodromal PD for each unit increase in motor symptoms score and for each kcal/kg/day lower energy expenditure, respectively. Gait speed less than 0.8 m/s was also linked to a higher prodromal PD probability score, excluding subthreshold parkinsonism from the calculation.
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