Hoban R, Poeliniz CM, Somerset E, et al. - Using regression models and Mann-Whitney tests, researchers sought to evaluate serial secretory activation biomarker concentrations (sodium [Na], potassium [K], Na:K ratio, protein, lactose, citrate) in mother’s own milk (MOM) from pump-dependent mothers of preterm infants to determine connections with coming to volume (CTV), defined as producing at least 500mL/day MOM by day 14 postpartum. Serial MOM samples were collected and MOM volume data were pumped for 14 days postpartum in mothers who delivered at < 33 weeks of gestation. Of 40 mothers, 39 had paired MOM volume and biomarker data (mean gestational age 28.8 weeks; 67% overweight/obese; 59% non-white); 33% had achieved CTV between days 6-14 postpartum. Secretory activation and CTV have been compromised in pump dependent mothers with preterm delivery. CTV has been predicted by MOM Na and Na:K ratios. As objective point-of-care measures, such biomarkers hold the potential to detect potentially modifiable lactation problems in a high-risk population.