Cortina G, et al. - Researchers investigated risk factors related to mortality in critically ill children undergoing continuous renal replacement therapy at a tertiary and quaternary referral 30-bed PICU. In this retrospective observational study based on a prospective registry, high mortality was observed among the participants. There seemed a link between mortality and underlying disease, the severity of illness, and the degree of fluid overload. Among overall 161 patients, the estimated overall mortality was 36% (n = 58). Patients on extracorporeal membrane oxygenation vs those not needing extracorporeal membrane oxygenation had significantly higher overall mortality. The factors that were independently related to mortality in the multivariate logistic regression analysis were the presence of higher severity of illness score at admission, onco-hematologic disease, fluid overload 10%–20%, greater than 20%, and timing of initiation of continuous renal replacement therapy. Overall, mortality might be decreased in critically ill children at high risk for developing acute kidney injury and fluid overload by ensuring earlier initiation of continuous renal replacement therapy.