Bauer M, Gerlach H, Vogelmann T, et al. - Given the association of sepsis and septic shock with mortality in critically ill patients, researchers sought to update and enhance the existing knowledge from meta-analyses and determine 30- and 90-day mortality rates for sepsis and septic shock separately, stratify rates by region and study type and determine mortality rates across different sequential organ failure assessment (SOFA) scores. Searching PubMed or the Cochrane Database, they identified 4500 records. Among 783 of these articles that were assessed in full text for eligibility, 170 studies were included in this study. Average 30-day septic shock mortality was 34.7% and sepsis mortality was 24.4%, and average 90-day septic shock mortality was 38.5% and sepsis mortality was 32.2%. Per 1-point raise in average SOFA score, there was an increase in average mortality by 1.8%–3.3%. Observations revealed trends of lower sepsis and continuous septic shock mortality rates over time and regional disparities; this indicates a remaining unmet need for improving sepsis management.