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Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: A multicentre, international, prospective cohort study

The Lancet Jul 28, 2021

Wright NJ, Leather AJM, Ade-Ajayi N, et al. - In this multicentre, international prospective cohort study, researchers prospectively compared the outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries, and identified factors associated with mortality. They involved 3,849 patients from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries with 3,975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease). There are unacceptable disparities in mortality for gastrointestinal congenital anomalies between low-, middle-, and high-income countries. Improving access to quality neonatal surgical care in low-income and middle-income countries will be critical to achieving Sustainable Development Goal 3.2, which calls for the abolition of preventable deaths in neonates and children under the age of five by 2030.

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