Castro VM, Gunning FM, McCoy TH, et al. - This study was intended to examine the relationship between prior mood disorder diagnosis and hospital outcomes among individuals admitted with COVID-19 to six Eastern Massachusetts hospitals. Researchers conducted a retrospective cohort from the electronic health records of two academic medical centers and four community hospitals between February 15 and May 24, 2020. They analyzed the relationships between the history of mood disorder and in-hospital mortality and hospital discharge home using regression models among hospitalized patients with positive tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this analysis, 717 (24.0%) had a prior mood disorder diagnosis among 2,988 admitted individuals. The results revealed that hospitalized individuals with a history of a mood disorder may be at risk for higher COVID-19 morbidity and mortality and are at greater risk of the need for postacute care. Future trials are needed to evaluate the mechanism by which these disorders may confer elevated risk.