Keeton CP, Caporino NE, Kendall PC, et al. - Considering the potential of youth anxiety interventions to reduce the risk for depression and suicidality, researchers conducted this naturalistic follow-up of the multi-site, comparative treatment trial, inking and behavior, and depressive symptoms 3–11 years (mean 6.25 years) following 12-week evidence-based youth anxiety treatment. Semiannual questionnaires were administered to participants (N = 319; 10–26 years, mean 17 years) in addition to conducting diagnostic interviews among them for 4 years. DSM-IV criteria for a mood disorder were met by one-fifth (20.4%) of the sample, suicidal ideation was reported by 32.1%, and suicidal behavior was reported in 8.2%. Reduction in the risk for subsequent chronic depressive symptoms and suicidal behavior was observed in correlation to effective early treatment of youth anxiety, including cognitive behavior therapy [CBT], medication, or CBT + medication. Odds of developing a mood disorder, chronic depressive symptoms, and suicidality could be reduced via considering (sub)clinical depressive symptoms and managing negative life events. These findings strengthen the evidence proposing that early intervention for a primary disorder could serve as secondary prevention.