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Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups

Modern Pathology Aug 16, 2017

Parra–Herran C, et al. – This research aspired to categorize the ovarian endometrioid carcinoma into prognostically significant groups via classification algorithm for endometrial carcinoma. It was found that the ovarian endometroid carcinoma could be classified into clinically significant subgroups by testing for molecular surrogates, akin to endometrial cancer. The mismatch repair proteins (MMR), and polymerase Ζ (POLE) alterations determined a subset of ovarian endometrioid carcinomas with a remarkable outcome; conversely, abnormal p53 carries a worse prognosis. The use of these markers in the routine evaluation of ovarian endometrioid tumors ought to be considered.
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