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Modifiable lifestyle factors for primary prevention of CKD: A systematic review and meta-analysis

Journal of the American Society of Nephrology Sep 04, 2020

Kelly JT, Su G, Zhang L, et al. - Researchers analyzed 104 studies with 2,755,719 participants, to assess the consistency of evidence connecting modifiable lifestyle factors and CKD incidence. These studies were identified from MEDLINE, Embase, CINAHL. This analysis involved cohort investigations with adults without CKD at baseline that stated lifestyle exposures (diet, physical activity, alcohol intake, and tobacco smoking). Significantly reduced odds of CKD were noted in relation to both higher dietary potassium consumption and higher vegetable intake; higher salt intake was found to be related to significantly raised odds of CKD. Lower odds of CKD were observed in correlation with being physically active vs sedentary. Significantly increased odds of CKD were observed in relation to current and former smoking vs never smoking. Moderate intake of alcohol was related to attenuated risk of CKD vs no intake. Overall, this work unveils the lifestyle factors that are modifiable and are consistently predictive of CKD incidence in the community and may inform both public health suggestions and clinical practice.

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