Barends CRM, Driesens MK, van Amsterdam K, et al. - Given that protocol-based target-controlled infusions (TCIs) of propofol and remifentanil are used to provide moderate-to-deep sedation by nursing staff trained and supervised by the anesthesia department in the University Medical Center Groningen in Groningen, the Netherlands, researchers determined the incidence of events with potential adverse health results within this service model as well as the risk factors for the development of these events, by performing this retrospective cohort analysis. They examined data from 2,937 procedures. Catastrophic events (death, need for cardiopulmonary resuscitation, or unplanned ICU admission) were not experienced by any of the patients. In 32 procedures, 32 severe sedation-related events happened. The most common severe events were severe desaturation and severe hypertension. According to the findings, a low incidence of catastrophic and severe events was reported in relation to moderate-to-deep sedation by propofol and remifentanil TCI.