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Mitral regurgitation following acute myocardial infarction treated by percutaneous coronary intervention—prevalence, risk factors, and predictors of outcome

The American Journal of Cardiology Aug 22, 2021

Sharma H, Radhakrishnan A, Nightingale P, et al. - Mitral regurgitation (MR) following acute myocardial infarction (AMI) developed in over one-quarter of patients and was related to lower survival, even when mild. MI subtype did not impact prevalence as well as severity of MR, however, delayed revascularization post-non-ST elevation myocardial infarction more commonly led to MR development.

  • A total of 1000 patients admitted with AMI in 2016/17 managed by percutaneous coronary intervention were included.

  • Presence of MR was detected in 294 of 1000 (29%) cases.

  • Older age, worse left ventricular ejection fraction (LVEF) and creatinine clearance, and higher rates of hypertension, heart failure, previous MI and severe flow-limitation in the circumflex or right coronary artery were noted in MR cases vs patients without MR.

  • Deaths of 56 of 288 (19%) patients with untreated MR were recorded following a mean of 3.2 years.

  • Age and LVEF were revealed as independent predictors of mortality.

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