Díez-Villanueva P, et al. - Researchers evaluated the prognostic impact of mitral regurgitation (MR) in elderly patients with non-ST-segment elevation myocardialinfarction (NSTEMI) in a multicenter prospective registry. In one-fifth of octogenarians with NSTEMI, they detected the presence of significant MR. Those with significant MR were older and had worse baseline clinical status, with higher frailty, disability, and risk of malnutrition vs those without significant MR. Lower systolic blood pressure, higher heart rate, worse Killip class, lower left ventricular ejection fraction, higher pulmonary pressure on admission, as well as more often new onset atrial fibrillation were detected in patients with significant MR. A poor prognosis was observed in patients with significant MR, which was mainly determined by their baseline clinical features.