Steinhaus ME, Iyer S, Lovecchio F, et al. - In this prospective cohort study, adult individuals who underwent cervical spine surgery at a single institution between 2016 and 2018 were prospectively recruited in order to build minimal clinically important difference (MCID) and substantial clinical benefit (SCB) thresholds for Patient-Reported Outcomes Measurement Information System (PROMIS) in cervical spine pathology. A total of 139 people with diagnoses of myelopathy (n = 36), radiculopathy (n = 48) and myeloradiculopathy (n = 49) were there. MCID of 4.9 Pain Interference (PI) and 4.5 Physical Function (PF) and SCB of 6.9 (PI) and 6.8 (PF) were reported. Moreover, these data propose the use of PROMIS computer adaptive tests in cervical spine individuals and give a significant reference as PROMIS reporting becomes more popular in the literature.