Kuehn K, et al. - Given that hypophosphatasia (HPP) is a rare inherited metabolic disorder characterized by deficient activity of the tissue-nonspecific alkaline phosphatase involving impaired turnover of phosphorus metabolites, researchers conducted this investigation to analyze the impact of dietary mineral intake on clinical HPP symptoms. Cross-sectional matched-pairs study gathering comprehensive data on nutrient intake in 20 patients with HPP and 20 unaffected, age- and gender-matched controls. Differences in phosphorus and calcium (Ca/P) ratio and uptake of magnesium, zinc, and vitamin B6 were not significant statistically. An increased Ca/P ratio was correlated with increased tiredness/fatigue, while a decreased Ca/P was related to gastrointestinal issues. Phosphorus and calcium intake appear to be reduced in HPP patients, along with reduced overall energy consumption. A higher incidence of clinical symptoms are associated with particularly high as well as very low absolute or unbalanced phosphorus and calcium intakes.