Vogt KM, Ibinson JW, Smith T, et al. - This study was undertaken to investigate whether midazolam and ketamine would decrease recollection memory, task-related brain activity, and long-range connectivity between components of the brain systems for memory encoding, pain processing, and fear learning. Researchers designed a randomized within-subject crossover study of 26 healthy adults using behavioral measures and functional magnetic resonance imaging to study these two anesthetics, at sedative doses, in an experimental memory paradigm using periodic pain. This study’s findings demonstrate that the painful stimulation during light sedation with midazolam, but not ketamine, can be accompanied by elevated coherence in brain connectivity, even though details are less likely to be recollected as explicit memories.