Ghumra W, Lee N, Whitehouse H, et al. - Researchers, for the first time, established a microRNAs (miRNA) signature for acne, and acne-associated atrophic scarring and identified whether a pattern of circulating miRNA is evident in patients who are prone to scarring. Forty-one candidates were consecutively selected for this investigation. In all 41 individuals, circulating miRNA was measured in plasma samples. Three miRNAs, miR-223, miR-21, and miR-150, were found to be statistically significantly overexpressed in acne lesions, as well as clinically uninvolved skin in scarring participants. The authors also discovered statistically significant increases in circulating miRNA-21 and miRNA-150 levels in this subgroup. The presence of elevated levels of these specific miRNAs in the serum of acne patients raises the possibility of a blood test identifying those at risk of scarring, allowing for earlier intervention with effective therapy.