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MicroRNA-15b targets VEGF and inhibits angiogenesis in proliferative diabetic retinopathy

Journal of Clinical Endocrinology & Metabolism Sep 16, 2020

Yang Y, Liu Y, Li Y, et al. - Researchers conducted the study for determining the role of specific micro ribonucleic acids (RNAs) (miRs) correlated with vascular endothelial growth factor (VEGF) in patients with proliferative diabetic retinopathy (PDR) pathology. In patients with diabetes mellitus (DM), nonproliferative diabetic retinopathy (NPDR), and PDR, RNA sequencing was used to detect differentially circulating miR associated with VEGF. In patients with PDR, circulating miR-15b was directly linked to VEGF vs other miRs. A significant inverse connection was found between low levels of miR-15b and high levels of VEGF in patients with PDR when compared with the DM or NPDR groups. Findings suggested that circulating miR-15b is correlated with PDR and may be targeted to regulate VEGF expression and angiogenesis.

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