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MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in nondiabetic and type 2 diabetic patients

Journal of Clinical Periodontology Mar 14, 2018

Roganovic J, et al. - The levels of miR-146a and miR-155 and superoxide dismutase (SOD) activity were investigated by the experts in gingival crevicular fluid (GCF) of periodontitis patients with (CPDM) and without (CP) DM type 2 as well as in periodontally healthy, control groups (PHDM and PH, respectively). They noted that the expression levels of microRNAs (miRs) were positively associated with SOD activity. Compared to PH patients, the levels of miR-146a were higher in PHDM. In nondiabetic and type 2 diabetic patients, miR-146a and miR-155 could be regarded as possible novel biomarkers for periodontitis.
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