Johnstone JM, Hatsu I, Tost G, et al. - In a population with ADHD and irritability, blinded clinician rating but not parent-report CASI-5 composite rating indicates micronutrients as globally beneficial over placebo.

• A total of 135 non medicated children (mean age 9.8 years) were randomized in a 3-site, 8-week, placebo-controlled, randomized clinical trial of micronutrients.

• The modified intention-to-treat population comprised 126 youths (93%).

• Both groups showed improvement in CASI-5 composite scores.

• No significant between-group difference was evident.

• Greater height growth by 6 mm was recorded in correlation with receiving micronutrients.

• Blood and urine tests did not show occurrence of any serious adverse events or clinically significant changes from baseline.

• Safety and efficacy described for ADHD in 2 smaller trials of a similar formula containing all vitamins and known essential minerals were replicated herein.