Johnstone JM, Hatsu I, Tost G, et al. - Researchers investigated the benefits, if any, of providing micronutrients (vitamins/minerals) to a North American pediatric sample for attention-deficit/hyperactivity disorder (ADHD) and irritability. In this three-site 8-week placebo-controlled randomized clinical trial of micronutrients, they radomized 135 unmedicated children (mean age 9.8 years) with ADHD and at least one impairing irritability symptom by parent report on the Child and Adolescent Symptom Inventory-5 (CASI-5). Findings indicated global benefit of micronutrients over placebo by blinded clinician rating, but not by parent-report CASI-5 composite rating in this population. Height growth was greater for cases receiving micronutrients. Participants showed good tolerability towards micronutrients and the majority adhered to the number of capsules prescribed. In line with the findings from two smaller trials of a similar formula that contained all vitamins and known essential minerals in amounts between the Recommended Dietary Allowance and Upper Tolerable Intake Level, this RCT supports safety and efficacy of micronutrients for ADHD.