Grieger JA, et al. - Authors assessed 5,530 nulliparous females (low-risk) to determine the influence of maternal metabolic syndrome (MetS) on pregnancy in the multi-center, international prospective Screening for Pregnancy Endpoints (SCOPE) cohort between November 11, 2004 and February 28, 2011. They defined MetS as per the International Diabetes Federation guidelines for adults (ie, waist circumference ≥80 cm, along with any 2 of the following: raised triglycerides [≥150 mg/dl], reduced high-density lipoprotein cholesterol [<50 mg/dl], raised blood pressure [systolic BP ≥130 mm Hg/diastolic BP ≥85 mm Hg], or raised plasma glucose [≥5.6 mmol/l]). After adjustment for demographic and lifestyle variables, women with MetS early in pregnancy had an increased risk for gestational diabetes mellitus and preeclampsia. A MetS diagnosis may help to roughly recognize women at risk for pregnancy complications, which could also be linked with future CVD risk.