JA Grieger, et al. - Researchers performed this retrospective cohort study of 5519 low-risk nulliparous pregnant women, to determine the correlation between metabolic syndrome (MetS), time to pregnancy (TTP), and infertility and correlations between individual and an increasing number of MetS components, TTP, and infertility. In addition, they assessed the influence of body mass index (BMI < 30 kg/m² vs BMI ≥ 30 kg/m²) on these relationships. They determined metabolic health via analyzing data on retrospectively reported TTP (number of months to conceive) and a blood sample collected between 14 and 16 weeks of gestation. Observations revealed MetS in 12.4% (n = 684) women among 5519 women analyzed. Longer TTP and infertility were noted in correlation with metabolic syndrome, independent of obesity. The main individual components associated with risk for infertility were reduced high-density lipoprotein cholesterol (HDL-C) and raised triglycerides (TGs).