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Metabolic dysfunction-associated fatty liver disease and incident cardiovascular disease risk: A nationwide cohort study

Clinical Gastroenterology and Hepatology Dec 26, 2020

Lee H, Lee YH, Kim SU, et al. - In view of the proposal by an international expert panel for a new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) as a name change from nonalcoholic fatty liver disease (NAFLD), researchers sought to determine the clinical impact of this change on the assessment of cardiovascular disease (CVD) risk via determining the prevalence of fatty liver disease (FLD) and the linked CVD risk using each of these definitions. From a nationwide health screening database, 9,584,399 participants (48.5% male) aged 40-64 years, they found NAFLD and MAFLD prevalences of 28.0% and 37.3%, respectively. Risk for CVD events was noted to be significantly higher in correlation with both NAFLD and MAFLD. Overall findings revealed MAFLD in a considerable proportion of middle-aged Korean adults not satisfying the former definition of NAFLD. Hence a greater number of individuals with metabolically complicated fatty liver and increased risk for CVD may be identified with the change from NAFLD to MAFLD criteria.

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