de Medeiros S, et al. – This study was undertaken to investigate the anthropometric, and metabolic connections of 17–hydroxypregnenolone in the normo– and hyperandrogenemic polycystic ovary syndrome phenotypes. As per the findings, 17–hydroxypregnenolone (17–OHPE) exhibited different relationships with anthropometric, and biochemical parameters in polycystic ovary syndrome (PCOS) patients, depending on the androgen levels. In PCOS subjects with high androgen concentrations,it was indicated that 17–OHPE was negatively correlated with most anthropometric parameters, particularly with those used as markers of adipose tissue dysfunction and frequently employed as predictors of cardiovascular disease risk; otherwise, 17–OHPE was positively correlated with HDL–C and HOMA–S in this patients. Future studies are needed to evaluate the clinical implications of these novel findings.