Limones M, et al. - Researchers assessed the changes in glucose tolerance, as well as in liver and adipose tissue metabolism consequent to 40% food restriction during the first 12 days of gestation in Sprague–Dawley pregnant rats. They investigated if a nutritional insult during early gestation favours an altered metabolic state of the mother that persists during the remainder period of pregnancy, when foetal growth is maximal. They found altered liver and adipose tissue metabolism as well as exacerbation in maternal insulin resistance at late gestation (which may increase their risk of gestational diabetes) consequent to undernutrition during the first half of pregnancy.