Zhang J, Liu Z, Hu S, et al. - This meta-analysis was undertaken to determine if genetic polymorphism of ARMS2 A69S could confer susceptibility to advanced age-related macular degeneration (AMD) with the response to anti-vascular endothelial growth factor (VEGF) treatment. In total, 21 preferred studies regarding the link between ARMS2 gene and anti-VEGF treatment response in advanced AMD were generally involved. The data presented in this work showed a significant connection between ARMS2 A69S polymorphism and the anti-VEGF treatment response in advanced AMD, particularly among East Asian population. To confirm  the correlation, numerous well-designed, randomized, multicenter clinical trials with large sample size are needed.