Eckshtain D, Kuppens S, Ugueto A, et al. - Given a 2006 meta-analysis indicating modest benefits of psychotherapy vs control for youth depression, a debilitating condition that constitutes a major public health concern, researchers examined how this picture has changed with 13 more years of research. Searching PubMed, PsychINFO, and Dissertation Abstracts International for 1960 to 2017, they identified 655 randomized, English-language psychotherapy trials for individuals aged 4 to 18 years. The analysis revealed an overall effect size (g) of 0.36 at posttreatment and 0.21 at follow-up (averaging 42 weeks after posttreatment). Identification of three moderator effects was made: significantly larger effects were noted for interpersonal therapy vs cognitive behavioral therapy, for youth self-reported outcomes vs parent-reports, and for comparisons with inactive control conditions (eg, waitlist) vs active controls (eg, usual care). Effects showed specificity, with significantly smaller effects for anxiety and externalizing behavior outcomes than for depression measures. Outcomes reveal the modest effect of youth depression psychotherapy, with no significant change over the past 13 years.