Yun D, Kim DK, Oh KH, et al. - Given Henoch-Schönlein purpura nephritis (HSPN) shares renal pathological characteristics with immunoglobulin A nephropathy, and despite the update of Oxford classification of immunoglobulin A nephropathy pathology to the MEST-C score, its application in HSPN is unresolved, so, researchers performed this study with 213 patients with biopsy-confirmed HSPN, to determine the value of the recently updated MEST-C score in predicting long-term renal outcomes in this patient population. Nephropathologists reviewed all kidney biopsy slides and scoring was done as per the revised Oxford classification criteria: mesangial hypercellularity (M0 < 50%; M1 ≥ 50% of the glomeruli), endocapillary hypercellularity (E0: absent; E1: present), segmental glomerulosclerosis (S0: absent; S1: present), tubular atrophy and interstitial fibrosis (T0: 0–24%; T1: 25–49%; and T2: ≥ 50% of the cortical area), and cellular or fibrocellular crescents (C0: absent; C1: 1–24%; and C2: ≥ 25% of the glomeruli). Worse renal outcomes in children were revealed by M1 and T1/T2 scores vs M0 and T0 scores, respectively, whereas, in adult patients, T score was identified as the only factor associated with worse outcomes, after adjusting for multiple clinical as well as laboratory variables. Overall, the prediction of long-term renal outcomes in patients with HSPN was enabled by Oxford classification MEST-C scores.