Hess K, Gliem M, Issa PC, et al. - Researchers conducted the study for quantifying mesopic and scotopic light sensitivity and identifying its microstructural correlates associated with a diseased Bruch membrane in patients with pseudoxanthoma elasticum (PXE). For this prospective, single-center, cross-sectional case-control study, mesopic and dark-adapted 2-color fundus-controlled perimetry (microperimetry) and multimodal retinal imaging including spectral-domain optical coherence tomography (SD-OCT) and OCT angiography were conducted. The sample consisted of 22 patients with PXE [15 were women (68%); median age 56.5 years (interquartile range, 50.4-61.2)]. In this investigation, among 22 PXE patients with and without choroidal neovascularization, retinal sensitivity reductions were found to be most prominent in dark-adapted cyan testing. This result indicates that rod photoreceptor degeneration and/or dysfunction may be dominated by pathological features of this Bruch membrane disease. A putative pigment-epithelium-photoreceptor separation can further impair rod function, whereas inner retinal abnormalities tend to be associated with overall dysfunction.