El Khoudary SR, Aggarwal B, Beckie TM, et al. - Researchers explored whether menopause transition (MT) contributes to the increment in coronary heart disease risk in women. They found that longitudinal studies over the past 20 years of women transitioning through menopause have reported distinct patterns of sex hormone alterations, and also adverse changes in body composition, lipids and lipoproteins, and measures of vascular health over the MT, which can raise their risk of developing cardiovascular disease (CVD) after menopause. Information now available regarding the contribution of the MT to raised CVD in women is not incorporated into the 2011 American Heart Association guidelines for CVD prevention in women (the latest sex-specific guidelines to date). Thus, to raise the awareness of the significant adverse cardiometabolic health–related alterations accompanying midlife and the MT, there is essentially a requirement to discuss the contemporary literature concerning menopause and CVD risk. An up-to-date synthesis of the existing data about the MT and how it is associated with CVD is afforded by this scientific statement.