Manson JE, Aragaki AK, Bassuk SS, et al. - In this randomized trial with 9,939 women (aged 50 to 79 years) with a previous hysterectomy and known oophorectomy status, researchers investigated outcomes of estrogen therapy by bilateral salpingo-oophorectomy (BSO) status, with additional stratification by 10-year age groups. The intervention included conjugated equine estrogens (CEE) (0.625 mg/d) or placebo for a median of 7.2 years. According to findings, CEE's effects in the overall cohort did not differ significantly by BSO status, but some results varied according to age. Women with prior BSO had adverse effects with CEE during the treatment period when they were 70 years of age or older; a long-term benefit in terms of mortality was seen in women randomly assigned to CEE before age 60. Irrespective of age, no significant relationship was found between CEE and outcomes in women with conserved ovaries.