Milosavljevic A, et al. - Authors assessed melatonin (MEL) levels in human dental pulp tissue (hDP) in type 2 diabetic (T2D) participants and the underlying molecular mechanisms of its effects in human dental pulp cells (hDPCs) under hyperglycaemia. Findings suggested that decreased MEL in hDP was seen in type 2 diabetic participants. For hDPCs, MEL was not cytotoxic at pharmacological concentrations. It was seen to normalizes inducible NO synthase (iNOS) and superoxide dismutase (SOD) activity levels in hyperglyceamic hDPCs suggesting its antioxidant and protective effects in human dental pulp tissue under hyperglycaemia.