Ferrara G, et al. - In this report, researchers summarized three instances of interface dermatitis of the head/neck area with clinicopathological characteristics of melanotic discoid lupus erythematosus/lichen planus pigmentosus. Such cases displayed junctional aggregates, some composed of inflammatory cells and colloid bodies (“pseudomelanocytic nest”), and some others composed of S100- but MART-1+, MITF+, and SOX-10+ cells (“true melanocytic nests”); negativity of the melanocytic component for PRAME was a clue to benignity. True junctional melanocytic nesting on chronically sun-damaged skin may be induced by lichenoid dermatoses. In order to avoid misdiagnosis, the existence of colloid bodies and the double negativity to S100 (within the nests) and PRAME (within both the nests and the single melanocytes) that warrant clinicopathological correlation.