Kamradt M, et al. – In this study, researchers investigated the effect of a care management intervention that focused on self-care behavior improvement among multimorbid individuals with type 2 diabetes mellitus on health-related quality of life (HRQoL) via hierarchical linear modeling. This investigation was conducted with 32 primary care practice teams, 11 care managers, and 495 patients. After 9 months, small improvements of HRQoL in the intervention arm were noted. However, no significant differences in HRQoL changes were observed vs standard care. For several other subgroups, no significant differences were observed between intervention and control arms, including subgroups defined by comorbidities. Additional care management did not affect HRQoL over and above standard disease management. Improving self-care behavior in the context of structured disease management programs may be difficult to achieve for patients with diabetes. According to findings, additional care management may be beneficial for women; however, this finding warrants further study.